Mortal Kombat vs. DC Universe is a crossover fighting game between the Mortal Kombat and DC comics universes. It was the last project developed by Midway before going bankrupt and being acquired by Warner Bros. As a result of its scaled down violence, it was the first game in the Mortal Kombat franchise to receive a teen rating, primarily due to the inclusion of comic book super heroes. Its story was written by comic writers Jimmy Palmiotti and Justin Gray.

The game takes place after Raiden and Superman both repel invasions in their respective universes. An attack by both Raiden and Superman simultaneously causes the merging Shao Kahn and DC villain Darkseid, resulting in the creation of Dark Kahn whose existence causes the merging of the two universes.

New modes such as "Free-Fall Kombat" were also introduced. In such stages where it is allowed, two characters can battle in mid-air for the chance to land on top of the opponent to perform maximum damage. A "Test Your Might" mini-game is also worked into the gameplay. While fighting in certain areas, the player can smash the opponent through a series of walls and engage in a tug-of-war with the damage meter at the top of the screen. The player on the offense mashes buttons to increase damage, while the player on the defense mashes buttons to decrease damage taken.

Mortal Kombat vs. DC Universe was developed using Epic Games' Unreal Engine 3 and is available for the PlayStation 3 and Xbox 360 consoles. Most reviewers agreed that the game was entertaining and made good use of the DC license. However, a lack of unlockable features and toned down finishing moves garnered some negative criticism.

When a cataclysmic force merges conquerors from two universes conflict is inevitable. Kombat forces friends to fight, worlds to collide, and unlikely alliances to be forged. In order to save all they know, the heroes and villains of Mortal Kombat must wage war against the combined might of the DC Universe. How can either side prevail when Rage blinds them to the dark threat poised to destroy them all? Which side will you choose?

Baraka (Playable),  Batman (Playable),  Catwoman (Playable),  Dark Kahn (Final Boss),  Darkseid (Playable),  Deathstroke (Playable),  Flash (Playable),  Green Lantern (Playable),  Jax (Playable),  Joker (Playable),  Kano (Playable),  Kintaro (Sub-Boss),  Kitana (Playable),  Lex Luthor (Playable),  Liu Kang (Playable),  Raiden (Playable),  Scorpion (Playable),  Shang Tsung (Playable),  Shao Kahn/General Shao (Unlockable/Playable),  Shazam (Playable),  Sonya (Playable),  Sub-Zero (Playable),  Superman (Playable),  Wonder Woman (Playable)

Apokolips,  Batcave,  Fortress of Solitude,  Gotham City Roof,  Gotham City Street,  Graveyard,  Hell (MKvsDCU),  Lex Corp,  Metropolis,  Mountain Hangar,  Oan Senate,  Raiden's Temple,  Themyscira,  Throne Room,  UN Space Station,  Wu Shi Academy